程蕾蕾教授团队于Journalof Inflammation Research发表论文:ProtectiveEffect of Crocin on Immune Checkpoint Inhibitors-Related MyocarditisThrough Inhibiting NLRP3 Mediated Pyroptosis in Cardiomyocytes viaNF-κB Pathway
本文阐述了藏红花素治疗可部分改善ICIs相关心肌炎,并通过调节NF-κB通路抑制心肌细胞焦亡,本研究结果可能为治疗ICIs引起的心功能障碍提供一种新的治疗剂。
Zhang H, Lin J, Shen Y, Pan J, Wang C,Cheng L. Protective Effect of Crocin on Immune CheckpointInhibitors-Related Myocarditis Through Inhibiting NLRP3 MediatedPyroptosis in Cardiomyocytes via NF-κB Pathway. J InflammRes. 2022;15:1653-1666. Published 2022 Mar 5.doi:10.2147/JIR.S348464